Exploiting HIV and/or Host Genomic Information to Understand HIV Compartments or Reactivation in Individuals with Substance Use Disorders (R61/R33) | RFA DA 18 016

Opportunity Information: Apply for RFA DA 18 016

The National Institutes of Health (NIH) grant opportunity titled "Exploiting HIV and/or Host Genomic Information to Understand HIV Compartments or Reactivation in Individuals with Substance Use Disorders (R61/R33)" (Funding Opportunity Number RFA-DA-18-016) supports early-stage, exploratory research focused on HIV persistence and reactivation in people who have substance use disorders (SUDs). The core scientific goal is to use HIV genomic data and/or host genomic or nucleomic information to better understand how HIV establishes and maintains latency, how it behaves in different body "compartments" (such as blood versus tissue sites), and what factors may contribute to viral reactivation. In practical terms, this announcement is aimed at projects that can leverage modern genetic, genomic, and nucleus-level (nucleomic) approaches to answer why HIV can remain hidden despite treatment and why it may flare up again, specifically in the context of SUDs, where biology, immune function, treatment adherence, and co-morbidities can complicate HIV outcomes.

This opportunity uses the NIH R61/R33 funding mechanism, which is designed as a phased innovation pathway. The R61 phase generally supports proof-of-concept or feasibility work, while the R33 phase supports an expansion of the project once early milestones are met. That structure is meant to encourage high-impact, potentially higher-risk ideas while still ensuring that projects demonstrate early progress before moving into a larger, more developed stage of research. The funding instrument type is a grant, and the activity category is listed under education and health. The CFDA number associated with the program is 93.279, which corresponds to NIH/NIDA-related research support areas.

Eligibility is broad and includes many types of organizations that might contribute to biomedical research, community-engaged studies, or translational work. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other entities. The announcement also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, non-domestic (non-U.S.) entities/foreign organizations, and U.S. territories or possessions. Taken together, this reflects an intent to include a wide range of scientific and community stakeholders, including institutions that serve populations disproportionately affected by HIV and substance use.

Key administrative details include an original closing date of December 13, 2017, and a creation date of September 14, 2017. The award ceiling is listed as $650,000. While the posted data include a field for expected awards, the number is not provided in the source excerpt. Overall, the opportunity is best understood as NIH support for innovative genomics-driven research that can clarify the biology of HIV reservoirs, compartmentalization, and latency/reactivation dynamics in individuals with SUDs, with the longer-term public health purpose of informing better strategies to control, prevent rebound, and ultimately contribute to cure-related efforts in a population facing layered clinical and social risks.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Exploiting HIV and/or Host Genomic Information to Understand HIV Compartments or Reactivation in Individuals with Substance Use Disorders (R61/R33)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
• This funding opportunity was created on 2017-09-14.
• Applicants must submit their applications by 2017-12-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $650,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA DA 18 016

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: