Opportunity Information: Apply for RFA DA 18 016
The National Institutes of Health (NIH) grant opportunity titled "Exploiting HIV and/or Host Genomic Information to Understand HIV Compartments or Reactivation in Individuals with Substance Use Disorders (R61/R33)" (Funding Opportunity Number RFA-DA-18-016) supports early-stage, exploratory research focused on HIV persistence and reactivation in people who have substance use disorders (SUDs). The core scientific goal is to use HIV genomic data and/or host genomic or nucleomic information to better understand how HIV establishes and maintains latency, how it behaves in different body "compartments" (such as blood versus tissue sites), and what factors may contribute to viral reactivation. In practical terms, this announcement is aimed at projects that can leverage modern genetic, genomic, and nucleus-level (nucleomic) approaches to answer why HIV can remain hidden despite treatment and why it may flare up again, specifically in the context of SUDs, where biology, immune function, treatment adherence, and co-morbidities can complicate HIV outcomes.
This opportunity uses the NIH R61/R33 funding mechanism, which is designed as a phased innovation pathway. The R61 phase generally supports proof-of-concept or feasibility work, while the R33 phase supports an expansion of the project once early milestones are met. That structure is meant to encourage high-impact, potentially higher-risk ideas while still ensuring that projects demonstrate early progress before moving into a larger, more developed stage of research. The funding instrument type is a grant, and the activity category is listed under education and health. The CFDA number associated with the program is 93.279, which corresponds to NIH/NIDA-related research support areas.
Eligibility is broad and includes many types of organizations that might contribute to biomedical research, community-engaged studies, or translational work. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other entities. The announcement also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, non-domestic (non-U.S.) entities/foreign organizations, and U.S. territories or possessions. Taken together, this reflects an intent to include a wide range of scientific and community stakeholders, including institutions that serve populations disproportionately affected by HIV and substance use.
Key administrative details include an original closing date of December 13, 2017, and a creation date of September 14, 2017. The award ceiling is listed as $650,000. While the posted data include a field for expected awards, the number is not provided in the source excerpt. Overall, the opportunity is best understood as NIH support for innovative genomics-driven research that can clarify the biology of HIV reservoirs, compartmentalization, and latency/reactivation dynamics in individuals with SUDs, with the longer-term public health purpose of informing better strategies to control, prevent rebound, and ultimately contribute to cure-related efforts in a population facing layered clinical and social risks.Apply for RFA DA 18 016
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Exploiting HIV and/or Host Genomic Information to Understand HIV Compartments or Reactivation in Individuals with Substance Use Disorders (R61/R33)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2017-09-14.
- Applicants must submit their applications by 2017-12-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $650,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Exploiting HIV and/or Host Genomic Information to Understand HIV Compartments or Reactivation in Individuals with Substance Use Disorders (R61/R33)" and the Funding Opportunity Number is RFA-DA-18-016.
Which NIH organization is associated with this funding opportunity?
The opportunity is offered through the National Institutes of Health (NIH) and is associated with NIDA-related research support areas, as reflected by the CFDA number provided (93.279).
What is the main purpose of this grant opportunity?
The core purpose is to support early-stage, exploratory research that uses HIV genomic data and/or host genomic or nucleomic information to better understand HIV persistence, latency, compartmentalization across the body, and viral reactivation, specifically in individuals with substance use disorders (SUDs).
What scientific problems is this opportunity trying to address?
This funding opportunity focuses on questions such as: how HIV establishes and maintains latency, how HIV behaves in different body compartments (for example, blood versus tissue sites), and what factors may contribute to HIV reactivation in the context of SUDs.
What kinds of data or approaches does this announcement emphasize?
The announcement emphasizes leveraging modern genetic, genomic, and nucleomic approaches. It explicitly calls out the use of HIV genomic information and/or host genomic or nucleomic information to study HIV persistence and reactivation.
What does "HIV compartments" mean in the context of this opportunity?
"Compartments" refers to different body sites where HIV may reside and behave differently, such as blood compared with tissue sites. The opportunity is aimed at research that helps clarify how HIV differs across these compartments.
Why is the focus specifically on individuals with substance use disorders (SUDs)?
The opportunity is focused on SUDs because HIV outcomes in this population can be complicated by factors such as biology, immune function, treatment adherence, and co-morbidities. The intent is to understand HIV persistence and reactivation dynamics within that context.
What funding mechanism is used (R61/R33), and what does it mean?
This opportunity uses the NIH R61/R33 phased innovation pathway. The R61 phase generally supports proof-of-concept or feasibility work, and the R33 phase supports project expansion after early milestones are met.
How do projects transition from the R61 phase to the R33 phase?
The structure is designed so that projects can move into the R33 expansion phase once early milestones are achieved during the R61 proof-of-concept/feasibility phase. The announcement highlights milestone-based progression, but specific milestone requirements are not provided in the excerpt.
Is this considered early-stage or later-stage research funding?
Based on the description provided, it is aimed at early-stage, exploratory research, with an initial feasibility/proof-of-concept phase (R61) followed by an expansion phase (R33) if milestones are met.
What is the funding instrument type?
The funding instrument type is a grant.
What activity category is this opportunity listed under?
The activity category is listed under education and health.
What is the CFDA number for this program and what does it indicate?
The CFDA number is 93.279. In the provided description, this CFDA is associated with NIH/NIDA-related research support areas.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include various government entities (state, county, city/township, and special district governments), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, Native American tribal governments (federally recognized), tribal organizations not federally recognized, public housing authorities/Indian housing authorities, nonprofit organizations with and without 501(c)(3) status (outside of higher education), for-profit organizations (other than small businesses), small businesses, and other entities.
Are minority-serving institutions and community-based organizations eligible?
Yes. The opportunity highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), as well as faith-based or community-based organizations and regional organizations.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility list includes non-domestic (non-U.S.) entities/foreign organizations.
Are U.S. territories or possessions eligible?
Yes. The eligibility list includes U.S. territories or possessions.
Are federal agencies eligible to apply?
Yes. The opportunity explicitly mentions eligible federal agencies among the additional eligible applicants.
What is the award ceiling for this opportunity?
The award ceiling is listed as $650,000.
How many awards does NIH expect to make under this opportunity?
The excerpt indicates that a field for expected awards exists, but the number of expected awards is not provided in the source information shared.
What are the key dates listed for this opportunity?
The creation date is September 14, 2017, and the original closing date is December 13, 2017.
What is the longer-term public health goal of the research supported by this grant?
The longer-term goal is to inform improved strategies to control HIV, prevent viral rebound, and contribute to cure-related efforts, especially for individuals with SUDs who may face layered clinical and social risks.
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