Opportunity Information: Apply for SP 25 002

The Strategic Prevention Framework - Partnerships for Success for Communities and Tribes (SPF-PFS-Communities/Tribes) is a discretionary grant opportunity from the Substance Abuse and Mental Health Services Administration (SAMHSA) focused on strengthening local prevention systems and expanding the reach and quality of substance use prevention services in communities and tribal settings. The program is designed to build prevention capacity across entire communities and tribes, with a strong emphasis on improving the ability of local prevention providers to plan, implement, and sustain effective prevention approaches over time rather than relying on short-term, one-off activities.

At its core, the grant aims to prevent and reduce the initiation of substance use and slow or stop the progression of substance use and related harms. It supports community-based prevention services that are meant to strengthen protective factors (the conditions that help people avoid substance use), reduce risk factors (the conditions that raise the likelihood of substance use), build resilience, and promote overall well-being. In practical terms, this means funding prevention work that targets the broader environments where people live, learn, work, and socialize, including families, schools, neighborhoods, and community systems, while also recognizing the specific cultural and contextual needs of tribal communities.

A major feature of the opportunity is its expectation that recipients will expand and strengthen the capacity of state and local community prevention providers serving communities and tribes. The grant specifically calls for the implementation of strategies that are evidence-based, evidence-informed, or community-defined evidence-based, signaling that applicants should rely on proven prevention models where possible, use the best available research and practice knowledge, and also incorporate approaches that have credible support and relevance within the community, especially in culturally grounded tribal contexts. This emphasis reflects SAMHSA's broader prevention framework that prioritizes data-driven planning, community engagement, and selecting interventions that can demonstrate meaningful impact.

Eligibility is limited to domestic public or private nonprofit entities. Examples explicitly included are community-based and faith-based organizations, federally recognized tribes, tribal organizations, local governments, and institutions of higher education. This eligibility scope is meant to ensure the funding goes to organizations with a public-serving mission and the ability to coordinate prevention activities at the community or tribal level, often in partnership with other local stakeholders.

Key administrative details include the funding opportunity number SP 25 002 and the CFDA (Assistance Listing) number 93.243, with awards made through a grant instrument. The application closing date is March 18, 2025. The maximum award amount (ceiling) is $600,000, and SAMHSA anticipates making about 52 awards. The opportunity was created on January 17, 2025.

  • The Substance Abuse and Mental Health Services Adminis in the health sector is offering a public funding opportunity titled "Strategic Prevention Framework - Partnerships for Success for Communities and Tribes" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.243.
  • This funding opportunity was created on 2025-01-17.
  • Applicants must submit their applications by 2025-03-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $600,000.00 in funding.
  • The number of recipients for this funding is limited to 52 candidate(s).
  • Eligible applicants include: Others.
Apply for SP 25 002

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Funding Number: CDC RFA CK 25 0144
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Circles of Care for American Indian/Alaska Natives (AI/AN) Apply for SM 25 016

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Connecting Kids to Coverage Outreach and Enrollment Cooperative Agreements (CKC) 2025 Apply for CMS 3Y3 25 001

Funding Number: CMS 3Y3 25 001
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Enhancing State No Wrong Door Systems for Efficient Access to Long-Term Services and Supports Apply for HHS 2025 ACL CIP NWGV 0029

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Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional) Apply for PAR 25 332

Funding Number: PAR 25 332
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Funding Number: PAR 25 374
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Advancing Vision Health Equity through Multi-level Interventions and Community-Engaged Research (R01 - Clinical Trial Optional) Apply for RFA EY 25 002

Funding Number: RFA EY 25 002
Agency: National Institutes of Health
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Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R21 Clinical Trial Optional) Apply for PAR 25 331

Funding Number: PAR 25 331
Agency: National Institutes of Health
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Funding Number: PAR 25 056
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Funding Number: PAR 25 099
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Funding Number: PAR 25 284
Agency: National Institutes of Health
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Funding Amount: $225,000
Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed) Apply for PAR 25 283

Funding Number: PAR 25 283
Agency: National Institutes of Health
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Funding Number: PAR 25 357
Agency: National Institutes of Health
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Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required) Apply for RFA DC 25 003

Funding Number: RFA DC 25 003
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Funding Number: PAR 25 343
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