Opportunity Information: Apply for CDC RFA DD 23 0003
The Centers for Disease Control and Prevention (CDC), within the Department of Health and Human Services (HHS) and specifically the National Center on Birth Defects and Developmental Disabilities (NCBDDD), is funding a cooperative agreement called Pregnant People-Infant Linked Longitudinal Surveillance (Funding Opportunity Number: CDC RFA DD 23 0003; NOFO referenced as DD23-2303). The core goal is to support systems that can follow and link health information from pregnancy through infancy and into childhood, so public health programs and clinical partners can better understand how certain exposures during pregnancy relate to outcomes for pregnant people, infants, and children over time. Rather than relying on one-time snapshots, the project is designed to produce multi-year, connected data that can inform faster and more accurate public health action.
The program emphasizes building and maintaining “mother-infant linked longitudinal surveillance,” meaning the funded work should connect data about the pregnant person and the infant (and potentially later child outcomes) across multiple sources and timepoints. CDC describes two complementary ways of doing this: a clinic-based approach and a health department-based approach. In practical terms, that can involve collecting information directly from clinical sites, integrating information from electronic health records, and/or performing linkages across systems such as vital records, laboratory data, hospital discharge datasets, immunization registries, or other public health and healthcare data sources. The intention is to create richer, more complete datasets that track exposures and outcomes over several years, improving the ability to detect trends, assess risks, and evaluate outcomes that may not be well captured through existing national reporting.
A major purpose of the cooperative agreement is to sustain, improve, and expand existing surveillance capacity, rather than treating surveillance as a short-term research project. CDC signals a strong interest in timely reporting of key exposures and outcomes that affect pregnant people and infants, improving data quality, and sharing updated findings as outcomes evolve over time. The opportunity also highlights innovation, including the development of improved clinical strategies and the creation of a strong collaborative network across participating sites and jurisdictions. In other words, recipients are not only expected to collect and link data, but also to work in a coordinated way that supports learning across sites and strengthens consistent reporting practices.
The NOFO points to several priority exposures and outcomes that may be included. Examples named in the opportunity include medication for opioid use disorder (MOUD) and neonatal abstinence syndrome (NAS), reflecting ongoing public health needs related to opioid exposure and treatment during pregnancy. Cytomegalovirus (CMV) is also listed, which is a significant cause of congenital infection and can be associated with long-term outcomes in children. Stillbirths are mentioned as a priority outcome as well, with an important note that stillbirth surveillance is not intended to be longitudinal in the same way as the pregnancy-to-childhood follow-up components. Beyond the listed topics, CDC indicates the scope may include other conditions with serious impacts on pregnant people and infants, leaving room for additional exposures and outcomes that participating programs are positioned to monitor.
From a systems and infrastructure standpoint, CDC’s strategic focus areas include advancing interoperability, improving data quality and informatics, and strengthening public health reporting. Interoperability generally points to the ability of different data systems (clinical and public health) to exchange, interpret, and use information reliably, which is often a central challenge in longitudinal surveillance. Data quality and informatics priorities suggest work such as standardizing variables, validating case definitions, improving completeness and timeliness, and building pipelines that reduce manual reporting burden while improving accuracy. Strengthening reporting also implies better mechanisms for translating surveillance findings into actionable public health information, including more consistent and responsive communication between clinical partners and health departments.
Another key emphasis is follow-up of maternal, infant, and child outcomes, including diverse clinical and neurodevelopmental outcomes for children exposed to infectious and non-infectious threats that are not currently nationally notifiable. This matters because many conditions of high concern in pregnancy and early childhood are not uniformly tracked through mandatory national reporting systems, which can leave gaps in understanding prevalence, risk factors, and longer-term developmental impacts. By supporting linked longitudinal surveillance, CDC is aiming to fill those gaps with structured, multi-year monitoring that can identify outcomes that emerge later in childhood, not just in the newborn period.
In terms of logistics, the project period is four years, organized into four 12-month budget periods, with an anticipated start date of September 1, 2023. The opportunity is categorized as a discretionary award and uses a cooperative agreement funding instrument, which typically means recipients should expect substantial programmatic involvement from CDC (for example, collaboration on surveillance methods, data quality expectations, and cross-site coordination) rather than operating in a fully independent grant model. CDC anticipated making around 22 awards. The listing shows an award ceiling of 0, which usually indicates that a specific maximum per award was not provided in the summarized record and would need to be confirmed in the full NOFO or related budget guidance.
Eligibility is broad and includes many types of entities that could plausibly operate or partner on surveillance systems, such as state, county, and city governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (including small businesses); and other entities as described in the full eligibility text. The application was originally due April 10, 2023, with electronic submissions required by 11:59 pm Eastern Time on the due date.
Overall, the grant opportunity is designed to expand the nation’s capacity to monitor and understand how pregnancy exposures translate into infant and child health outcomes, using linked, longitudinal data that can support faster reporting, better quality information, and more coordinated public health response. The work is positioned at the intersection of clinical care data and public health surveillance, with a strong emphasis on modern data practices, cross-system linkages, and longer-term follow-up that extends beyond birth outcomes alone.Apply for CDC RFA DD 23 0003
- The Department of Health and Human Services, Centers for Disease Control - NCBDDD in the health sector is offering a public funding opportunity titled "Pregnant People-Infant Linked Longitudinal Surveillance" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.073.
- This funding opportunity was created on Feb 09, 2023.
- Applicants must submit their applications by Apr 10, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 22 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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